Considerations for clinical trial design and data analyses of thorough QT studies using drug-drug interaction.
نویسندگان
چکیده
منابع مشابه
Incidence of Potential Drug-Drug Interaction and Related Factors in Hospitalized Neurological Patients in two Iranian Teaching Hospitals
Background: Reciprocal drug interactions are among the most common causes of adverse drug reactions. We investigated the incidence and related risk factors associated with mutual drug interactions in relation to prescriptions written in the neurology wards of two major teaching hospitals in Shiraz, southern Iran. Methods: Data was collected from hand-written prescriptions on a daily basis. Mutu...
متن کاملDrug-Drug Interaction Clinical Decision Support Systems: Advantages, Challenges and Barriers, and Strategies to Overcome Them
Drug-drug interactions (DDIs) are a common source of preventable medical errors in inpatient and outpatient settings of both developed and developing countries. When two or more drugs are simultaneously prescribed, interactions between their effects may result in preventable adverse events such as damages to vital organs, frequent hospitalizations, prolonged length of hospital stay, and increas...
متن کاملDrug-Drug Interaction Clinical Decision Support Systems: Advantages, Challenges and Barriers, and Strategies to Overcome Them
Drug-drug interactions (DDIs) are a common source of preventable medical errors in inpatient and outpatient settings of both developed and developing countries. When two or more drugs are simultaneously prescribed, interactions between their effects may result in preventable adverse events such as damages to vital organs, frequent hospitalizations, prolonged length of hospital stay, and increas...
متن کاملA Multivariate Approach to Sample Size Calculations for Thorough QT Studies
Thorough QT studies are becoming a necessary part of the clinical profile of existing and investigational new drugs. The E14 guidelines mandate performing a thorough QT study on any non antiarrythmic drug to ensure that the drug does not produce a QT prolongation effect before it can be approved and marketed. The cost involved in running a thorough QT study is substantial and an adverse outcome...
متن کاملRecent Trends in the Management of Pulmonary Hypertension
Context. Pulmonary hypertension is a common clinical problem encountered in day-to-day practice. Drug therapy forms the backbone of management and appropriate drug selection is based upon the underlying causes. The options available are widening with availability of newer therapeutic agents and thus it becomes necessary to be updated with the recent developments. Objective. To review the existi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of clinical pharmacology
دوره 50 10 شماره
صفحات -
تاریخ انتشار 2010